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Filtered Search Results
Medchemexpress LLC N-METHYL QUINIDINE-D 1 mg
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N-METHYL QUINIDINE-D 1MG
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Medchemexpress LLC Quinidine (15% dihydroquinidine) | 56-54-2 | 98.36% | 5 G
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Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. It is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine also acts as a K+ channel blocker with an IC50 of 19.9 μM, and it can induce apoptosis. It can be used for malaria research.
- Antiarrhythmic agent: Helps in the treatment of irregular heartbeats.
- Potent, orally active, selective cytochrome P450db inhibitor: Targets and inhibits specific cytochrome P450 enzymes.
- K+ channel blocker: Blocks potassium channels with an IC50 of 19.9 μM.
- Induces apoptosis: Capable of triggering programmed cell death.
- Used for malaria research: Applicable in studies related to malaria.
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TARGETMOL CHEMICALS INC RESIQUIMOD 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells macrophages and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokines especially interferon-alpha (INF-a) and other cytokines thereby enhancing T-helper 1 (Th1) immune responses. In addition topical application of resiquimod appears to activate Langerhans' cells leading to an enhanced activation of T-lymphocytes. purity: 99%
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Apexbio Technology LLC Resiquimod (R-848) 144875-48-9 10mM (in 1mL DMSO)
Resiquimod (R-848) is an immunomodulatory small molecule structurally related to imiquimod It functions primarily by activating immune responses via inducing cytokine release In vitro studies with human peripheral blood mononuclear cells (PBMC) indicate that Resiquimod promotes dose-dependent production of cytokines including interferon-alpha (IFN- ) tumor necrosis factor (TNF) interleukin-1 (IL-1 ) and interleukin-6 (IL-6) Mechanistically Resiquimod increases intracellular IL-1 levels and both monocytes and B-cells respond by secreting IFN upon stimulation In addition it elevates mRNA expression of IFN- TNF and IL-8 in treated PBMC relative to untreated controls Resiquimod demonstrates antiviral and antitumor activities in preclinical animal models frequently utilized as an immune response potentiator and Toll-like receptor (TLR) agonist in biomedical investigations (IC50 values typically range in low micromolar)
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Medchemexpress LLC Imiquimod (maleate) | 896106-16-4 | 99.9% | 500 MG
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Imiquimod maleate (R 837 maleate) is an immune response modifier and a selective toll-like receptor 7 (TLR7) agonist. It demonstrates antiviral and antitumor effects in vivo. This product is an analytical standard intended for research and analytical applications, and can be used for research of external genital, perianal warts, cancer, and COVID-19, and to induce psoriasis models.
- Selective toll-like receptor 7 (TLR7) agonist
- Exhibits antiviral and antitumor effects in vivo
- Suitable for research of external genital, perianal warts, cancer, and COVID-19
- Can be used to induce psoriasis models
- Targets TLR7 and HSV-1
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Apexbio Technology LLC CP-673451 343787-29-1 200mg
CP-673451 (CAS 343787-29-1) is an ATP-competitive inhibitor with specificity for platelet-derived growth factor receptors (PDGFR- / ) It exhibits inhibitory potency with IC50 values of 10 nM for PDGFR- and 1 nM for PDGFR- while demonstrating significantly less inhibition toward kinases such as VEGFR-1 VEGFR-2 Lck TIE-2 and EGFR In cellular assays CP-673451 effectively inhibits PDGFR- phosphorylation in PAE- cells (IC50 6 4 nM) and reduces c-kit activity in H526 cells at micromolar range Its anticancer efficacy has been established by suppressing tumor growth and vascularization in xenograft models indicating its potential utility in cancer research and angiogenesis studies
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Medchemexpress LLC Purvalanol B (NG 95) | 212844-54-7 | 97.0% | 432.90 | 200 MG
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Purvalanol B (NG 95) is a potent, selective, reversible, and ATP-competitive inhibitor of cyclin-dependent kinases (CDK). It demonstrates significant selectivity for CDK over other protein kinases and effectively inhibits the growth of a chloroquine-resistant strain of *P. falciparum*.
- Potent, selective, reversible, and ATP-competitive inhibitor of CDK
- Inhibits cdc2-cyclin B, CDK2-cyclin A, and CDK5-p35 with IC50s of 6 nM
- Inhibits CDK2-cyclin E with an IC50 of 9 nM
- Shows selectivity for CDK over other protein kinases (IC50 > 1000 nM)
- Inhibits the growth of a chloroquine-resistant strain of *P. falciparum*
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Medchemexpress LLC Taselisib | 1282512-48-4 | 99.8% | 460.53 | 200 MG
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Taselisib (GDC-0032) is a potent PI3K inhibitor that selectively targets PIK3CA mutations, exhibiting Kis of 0.12 nM for PI3Kδ, 0.29 nM for PI3Kα, 0.97 nM for PI3Kγ, and 9.1 nM for PI3Kβ. It is provided as a white to off-white solid. Taselisib inhibits AKT/mTOR signaling in PIK3CA mutant cell lines and has been shown to enhance radiation-induced apoptosis and inhibit growth in head and neck cancer cell lines. In vivo studies demonstrate that it potently impairs PI3K signaling and enhances the efficacy of fractionated radiotherapy in xenograft models.
- Potent PI3K inhibitor targeting PIK3CA mutations.
- Inhibits AKT/mTOR signaling in PIK3CA mutant cell lines.
- Enhances radiation-induced apoptosis.
- Inhibits growth in head and neck cancer cell lines.
- Impairs PI3K signaling in vivo.
- Enhances efficacy of fractionated radiotherapy in animal models.
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Medchemexpress LLC Olumacostat glasaretil | 1261491-89-7 | 98.9% | 481.62 | 200 MG
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Olumacostat glasaretil | 1261491-89-7 | 98.9% | 481.62 | 200 MG
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TARGETMOL CHEMICALS INC TBA-7371 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. TBA-7371 (DprE1-IN-1) is a potent inhibitor of DprE1 and PDE6. purity: 99%
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Apexbio Technology LLC MNS 1485-00-3 200mg
MNS (CAS 1485-00-3) is a small molecule selectively inhibiting the tyrosine kinases Src and Syk It demonstrates antiaggregative activity by suppressing GPIIb/IIIa integrin activation with an IC50 of 12 7 M in thrombin-induced platelet aggregation assays MNS does not impact Ca2 -dependent enzymes protein kinase C or arachidonic acid pathways This selective kinase inhibition profile makes MNS a valuable tool for investigating platelet signaling mechanisms and the regulation of integrin-mediated cellular functions
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Medchemexpress LLC α-N-carbobenzoxy-L-lysine thiobenzyl ester monohydrochloride | 69861-89-8 | MFCD00058089 | 99.7% | C21H27ClN2O3S | 10MG
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Z-LYS-SBZL monohydrochloride is the monohydrochloride salt of a carbobenzoxy-protected lysine thiobenzyl ester. Supplied as a solid research reagent, it is used in biochemical assays, protease and esterase activity studies, and peptide synthesis workflows where a protected lysine derivative is required.
- High purity suitable for analytical and preparative work
- Available in small-scale pack sizes for research use
- Stable when stored sealed and away from moisture
- Soluble in common organic solvents for reaction compatibility
- Useful as a substrate or intermediate in protease and peptide studies
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Apexbio Technology LLC EMD638683 1181770-72-8 200mg
EMD638683 (CAS 1181770-72-8) is a selective inhibitor of serum- and glucocorticoid-inducible kinases (SGKs) including isoforms SGK1 SGK2 and SGK3 SGK1 regulates key cellular processes such as ion transport survival proliferation and responses to steroid hormones EMD638683 shows inhibitory activity against SGK1 SGK2 and SGK3 (IC50 3 M) significantly reducing SGK-dependent phosphorylation of NDRG1 in vitro It demonstrates limited off-target interactions inhibiting only MSK1 and PRK2 at 1 M while sparing numerous other kinases In cell models EMD638683 influences mitochondrial polarization and caspase activity exhibiting antitumor effects in colorectal tumor cells and antihypertensive activity in vivo
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Medchemexpress LLC PT2399 200 mg
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PT2399 200MG
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Medchemexpress LLC 50-C2-C9-4TAIL 1 mg
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50-C2-C9-4TAIL 1MG
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